Pokok Bunga Tahi Ayam merupakan spesies invasif dan melitupi sebahagian besar India, Australia dan kebanyakan Afrika.[12] Ia bertapak di kawasan baru apabila biji benihnya disebarkan oleh burung. Sebaik sahaja ia sampai di kawasan baru, Pokok Bunga Tahi Ayam tersebar dengan pantas. It coppices so well, that efforts to eradicate it have completely failed. It is resistant to fire, and quickly grows in and colonizes burnt areas.[13] It has become a serious obstacle to the natural regeneration of important native species including the Shala Tree (Shorea robusta) in Southeast Asia, as well as plants in 22 other countries. In greenhouses, L. camara is notorious for attracting whitefly.[7][14] In India they bear fruit all year round and this appears to have an impact on bird communities.[15]

While considered a pest in Australia, it shelters several native marsupial species from predators, and offers a habitat for the vulnerable Exoneura native bee, which nests in the hollow stems of the plant.

L. camara has been listed as a Category One "Invasive Toxic Species" in Florida by the Florida Exotic Pest Plant Council, and has become a problem in Texas and Hawaii.[3][14]